TY  - JOUR
A1  - Bartel, Theresa
A1  - Mortimer, Jeremy M
A1  - Zylka, Waldemar
A1  - Paxton, Jennifer
A1  - Vorstius, Jan Bernd
T1  - Design and Development of a Bioreactor System for Mechanical Stimulation of Musculoskeletal Tissue
T2  - Current Directions in Biomedical Engineering
N2  - We report on the development of a bioreactor system for mechanical stimulation of musculoskeletal tissues. The ultimate object is to improve the quality of medical treatment following injuries of the enthesis tissue. To this end, the tissue formation process through the effect of mechanical stimulation is investigated. A six-well system was designed, 3D printed and tested. An integrated actuator creates strain by applying a force. A contactless position sensor monitors the travels. An electronic circuit controls the bioreactor using a microcontroller. An IoT platform connects the microcontroller to a smartphone, enabling the user to alter variables, trigger actions and monitor the system. The system was stabilised by implementing two PID controllers and safety measures. The results show that the bioreactor design is suited to execute mechanical stimulation and to investigate the tissue formation and regeneration process …
Y1  - 2023
UR  - https://whge.opus.hbz-nrw.de/frontdoor/index/index/docId/4300
VL  - 9
IS  - 1
SP  - 122
EP  - 125
ER  -