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Investigation of avascular tumor–immune system interactions using a CA–PDE model

  • We report on investigations that illustrate the interaction between the specific immune system and a young avascular tumor growing due to a diffusive nutrient supply. We formulate a hybrid cellular automata-partial differential equation (CA-PDE) model which includes cell cycle dynamics and allows for tracking the spatial and temporal evolution of this elaborate biological system. We present results of two dimensional numerical simulations that, specifically in this work, include special cases of the spherical and papillary tumor growth, the infiltration of immune system cells into the tumor and the escape of tumor cells from the regime of the immune cells.

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Author:Waldemar Zylka, Jörg Waßenberg
Parent Title (English):Current directions in biomedical engineering
Document Type:Article
Date of Publication (online):2018/12/23
Year of first Publication:2018
Publishing Institution:Westfälische Hochschule Gelsenkirchen Bocholt Recklinghausen
Release Date:2019/01/14
First Page:615
Last Page:619
Departments / faculties:Fachbereiche / Elektrotechnik und angewandte Naturwissenschaften
Licence (German):License LogoEs gilt das Urheberrechtsgesetz

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